• A low power view of a chrondrosarcoma.
• It is best to view this field in association with a
similar magnification of normal cartilage.
• Notice the chaotic arrangement of the nuclei in this field and the hyperchromatic nature of these nuclei.
•The etiology of chondrosarcoma is unknown.
•Usually a tumor of
older age groups.
•Approximately twice as common in men as in women.
•No racial preferences have been noted.
•Most chondrosarcomas are slow growing, indolent tumors.
•Larger tumors behave more aggressively than smaller tumors.
•As with all sarcomas, spread is preferentially through the vascular
•Tumors are rare in the distal extremities.
•Most tumors arise from central skeleton including pelvis,
shoulders and ribs.
•Presenting symptoms are usually of a painful enlarging mass.
•For more information about prognosis and treatment, consult the NCI web site.
|General Gross Description|
•Tumors exhibit features of cartilage, including
ground substance and chondrocytes.
•Areas of calcification, necrosis and hemorrhage are seen in
rapidly growing tumors.
•Myxoid variants exhibit a viscous and gelatinous consistency.
•Cellular atypia increases with poorly differentiated tumors.
|General Micro Description|
•Histologically, chondrosarcomas can be divided into three
grades - gr
•Grade 1 tumors resemble normal cartilage closely, with little
deviation from normal histology.
•Grade 3 tumors can show considerable cellular atypia.
•Most common grade of chondrosarcoma is grade 1.
•More aggressive grades show areas of necrosis and hemorrhage.
•The myxoid variant exhibits areas of myxomatous matrix.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1240.