Medium power view of an osteosarcoma
Medium power view of an osteosarcoma

Note the intense cellularity of this lesion
The green arrows point to the large cells with extremely large, hyperchromatic nuclei.
These are the malignant cells of osteocytes origin
Note the acellular, pink staining material at the center of the field.
This is the organic matrix of bone, called osteoid.
The diagnostic feature of osteosarcoma is the presence of this malignant osteoid.
(Description By:T.V.Rajan, M.D. )
(Image Contrib. by:T.V.Rajan, M.D. UCHC )