• This specimen contains the bones
of the orbit in section.
• Note the blue lesion. This is the
• The dark color is due to the accumulation of de-oxygenated blood.
•Often noted in childhood.
•Present as blue
•Tumors are most often only of cosmetic significance.
•However, when present in the brain, hemorrhage can be
a lethal consequence.
•In von Hippel-Lindau disease, several of these lesions are
seen, in the cerebellum, brain stem and abdominal viscera.
|General Gross Description|
•Benign vascular malformation.
•Usually solitary; however, multiple cavernous hemangiomas
occur in a genetic disorder, called von Hippel-Lindau
•Grossly, cavernous hemangiomas are blue, soft and spongy.
|General Micro Description|
•Histologically, the lesion is characterized by large,
thin walled blood vessels completely filled with blood.
•In contrast to other hemangiomas, vascular channels are
of large diameter (hence, cavernous or like a cave).
•Evidence of previous hemorrhage often seen.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 507.