| Malignant Fibrous Histiocytoma
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Etiology
•Unknown
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Pathogenesis
•Unknown,
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Epidemiology
•Occur somewhat more frequently in
men.
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General Gross Description
•Grossly, they are large tan masses that are
frequently
associated with hemorrhage.
•They arise in the soft tissue of the body, and can erode
into bone and soft tissues.
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General Microscopic Description
•Histologically, malignant fibrous histiocytoma (MFH) consists of spindly fibroblasts with large numbers
of bizarre, multi-nucleated giant cells.
•There is a tendency of some of the mononuclear cells to resemble
histiocytes.
•The cells are typically arranged in a "storiform" or "carriage wheel" pattern radiating out like curved spokes from a central point.
•Mitoses are numerous which along with cellular pleomorphism and necrosis are indicative of the neoplasms high grade.
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Clinical Correlation
•These are usually
present as enlarging, painful masses that
often cause pathological fractures, due to destruction of bone by the neoplasm..
•The prognosis is poor with a 20% survival at five years.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1243.
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| Malignant Fibrous Histiocytoma
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| Synopsis by: T.V. Rajan M.D. Ph.D. (T1X000M88303)[87]
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