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| Fibroadenoma |
| Etiology • Unknown |
| Pathogenesis • Stromal component of the lesion is clonal • Derives from intralobular stroma • May arise within individual nodules and apparently "coalesce", |
| Epidemiology • Most common benign neoplasm in the breast • More frequent in women under 30 |
| General Gross Description • Gray-white, spherical nodule that is rubbery and mobile on palpation • Neoplasm can be "shelled out" of the surrounding breast tissue • In teenagers may reach enormous size (10-15 cms) so called juvenile fibroadenoma |
| General Microscopic Description • Consists of a proliferation of both ducts and stroma • Stroma contains numerous fibroblasts and palely eosinophilic cytoplasm • Broad birefringent collagen bands are absent until lesion involutes • Glandular spaces are lined by typical duct epithelium and may be compressed by fibrous proliferation |
| Clinical Correlation • Benign • Regress with menopause • Treatment by resection |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1097-8. |
| Fibroadenoma |
| Synopsis by: Melinda Sanders M.D. (T04000M90100)[318] |
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