•  This low power view demonstrates an intracystic proliferation.

•  There is a proliferation of finger-like processes into the lumen.

•  The fingers contain a fibrovascular stroma.

•  The lining epithelium contains duct epithelium and myoepithelial cells.

• Unknown

• Unknown.

• Responsible for up to 1/2 of abnormal nipple discharge

• Bloody nipple discharge or small subareolar mass

• Will recur if duct system not excised

• Duct papillomatosis (multiple small papillomas) is a component of proliferative breast disease

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• Usually in major nipple duct, close to nipple

• Usually < 1 cm. in size

• Multiple papillae with fibrovascular cores

• Cells overlying papillae resemble normal duct epithelial cells

• Myoepithelial cells also present

• Epithelial hyperplasia or apocrine metaplasia may be seen

• Single papillomas in lactiferous sinuses

• Small papillomas are multiple and deep

• Robbins Pathologic Basis of Disease. 7th ed., 2005, p. 1128-9.

• Current literature from PubMed at National Library of Medicine