• This low power view demonstrates an intracystic proliferation.
• There is a proliferation of finger-like processes into the lumen.
• The fingers contain a fibrovascular stroma.
• The lining epithelium contains duct epithelium and myoepithelial cells.
• Responsible for up to 1/2 of abnormal nipple discharge
• Bloody nipple discharge or small subareolar mass
• Will recur if duct system not excised
• Duct papillomatosis (multiple small papillomas) is a component of proliferative breast disease
|General Gross Description|
• Usually in major nipple duct, close to nipple
• Usually < 1 cm. in size
|General Micro Description|
• Multiple papillae with fibrovascular cores
• Cells overlying papillae resemble normal duct epithelial cells
• Myoepithelial cells also present
• Epithelial hyperplasia or apocrine metaplasia may be seen
• Single papillomas in lactiferous sinuses
• Small papillomas are multiple and deep
• Robbins Pathologic Basis of Disease. 7th ed., 2005, p. 1128-9.