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| Lobular Carcinoma in Situ |
| Etiology • Unknown |
| Pathogenesis • Unknown, ?BRCA1 mutations. • See discussion under infiltrating duct carcinoma, |
| Epidemiology • Increasing age • More frequent in women of low parity with first child after 30 • Increased in obesity • Increased in women with history of atypical hyperplasia • Increased in women with history of breast carcinoma • Increased in women with mother or sibling with breast cancer • Increased in women with mutations in BRCA1 or BRCA2 genes |
| General Gross Description • May be associated with microcalcifications within the lobules • Gross findings may be of fibrocystic change • May be associated with invasive carcinoma |
| General Microscopic Description • Distension of terminal ducts or ductules by solidly packed cells • Cells are slightly larger than normal with round to oval nuclei and small nucleoli • Cells may extend up into ducts |
| Clinical Correlation • Increased risk of breast cancer 10 fold |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1099-1103. |
| Lobular Carcinoma in Situ |
| Synopsis by: Melinda Sanders M.D. (T04000M85202)[309] |
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