• Low power view of a cellular tumor showing a "chicken
wire fence" type of stroma breaking the tumor into small
• This stromal pattern is common in the oligodendroglioma.
•The etiology of the oligodendroglioma is unknown but most tumors show abnormalties of chromosome 19 and 1.
•Oligodendrogliomas make up about 5% of intracranial
tumors and 10% of gliomas.
•They are relatively slow growing except for the anaplastic variety which is rare.
•Oligodendrogliomas act as mass lesions, infiltrating
areas of brain.
•If they infiltrate the motor area,
there are seizures of a focal motor type or
•Infiltrating sensory regions may produce
sensory symptoms or misinterpretations.
•They also are
associated with edema so can produce herniation.
|General Gross Description|
•Oligodendrogliomas are grey gelatinous masses in the
brain that act as mass lesions.
•They are more comman in the cerebral hemispheres.
|General Micro Description|
•The tumor is made up of uniform oval cells with clear
to pale pink cytoplasm and relatively uniform oval
to round nuclei that have a fried egg or "box like"
•The stroma is made up of capillaries having
a chickenwire appearance between groups of tumor cells.
•There is no good grading system and no specific immunoperoxidase stain to identify them.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1343-1345.
• Poirer J et.al. Manual of basic neuropathology. Philadelphia: Saunders, 1990, pp.26-27.