Schwannoma
Schwannoma
8;A higher power view of the Scwannoma showing the slender spindle cells with palisading nuclei. €Schwannomas are seen mosst commonly on the eighth nerve but may be seen on any sensory nerve root and occasionaly on motor roots.


(Image Contrib. by:UCHC)(Description by: Margaret Grunnet,M.D.)
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Schwannoma
Etiology

• Unknown.


Pathogenesis

• Proliferation of Schwann cells.


Epidemiology

• Sporadic

• Generally disease of adults

• Associated with sensory nerves, especially the 8th (acoustic neuroma) in an intracranial location, around the spine with extension through the vertebral foramina, or associated with major nerve trunks


Clinical

• Benign lesion treated by surgical resection.
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General Gross Description

• Encapsulated neoplasms which can be divided from the intact nerve.

• Neoplasms are adjacent to nerve which may splay over it

• Firm, gray lesions that may have degenerative changes.


General Micro Description

• Antoni A regions show lining up of delicate wavy nuclei in bands separated by eosinophilic cytoplasm

• Rows of nuclei are Verocay bodies

• Antoni B regions show less organization.

• S-100 reactive.


Reference

• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1352.


• Current literature from PubMed at National Library of Medicine


Synopsis by: Melinda Sanders M.D., UCHC
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