• Proliferation of Schwann cells.
• Generally disease of adults
• Associated with sensory nerves, especially the 8th (acoustic neuroma) in an intracranial location, around the spine with extension through the vertebral foramina, or associated with major nerve trunks
• Benign lesion treated by surgical resection.
|General Gross Description|
• Encapsulated neoplasms which can be divided from the intact nerve.
• Neoplasms are adjacent to nerve which may splay over it
• Firm, gray lesions that may have degenerative changes.
|General Micro Description|
• Antoni A regions show lining up of delicate wavy nuclei in bands separated by eosinophilic cytoplasm
• Rows of nuclei are Verocay bodies
• Antoni B regions show less organization.
• S-100 reactive.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1352.