• External view of a parathyroid adenoma.
• Smooth surface is typical of a benign neoplasm.
• Cannot separate hyperplasia from adenoma on the basis
of gross findings in one gland.
• Parathyroid carcinoma would probably show adhesions reflecting difficulty in dissecting it from adjacent invaded structures.
• secretes unregulated parathormone resulting in elevation of serum calcium
by renal retention, GI absorption and bone mobilization
• 25/100,000 in
• 3:1 female predominance
• age > 50
• usually detected in asymptomatic patient
• rarely see evidence of osteitis fibrosa cystica (due to osteoclast
activity and bone resorption) and renal stones
|General Gross Description|
• Occasionally can see compressed rim of normal parathyroid
|General Micro Description|
• Composed of any cell types within parathyroid
• No stromal or intracellular fat
• May see compressed rim of normal parathyroid
• Nuclear atypia and mitoses are NOT indicative of malignancy
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1144-146