Mycobacterium Avium Intracellulare + CMV

Mycobacterium Avium Intracellulare + CMV •The lamina propria is filled with histiocytes(black arrow) having ample pale pink granular or foamy cytoplasm •While the organism MAI can not be seen on H&E stains, the presence of clusters of characteristic histiocytes in an immunodeficiant host should create a high index of suspicion •The green arrow indicates a cell with an intranuclear inclusion diagnostic of CMV •CMV inclusions are uniformly deeply purple, occupy more than 50% of the nuclear diameter, and are surrounded by a clear zone with a rim of compressed nuclear chromatin (Description By:Martin Nadel, M.D. ) (Image Contrib. by:Martin Nadel, M.D. UCHC )