Acute Colitis
Acute Colitis
inflammatory infiltrate consists exclusively of polys, there is no necrosis. The epithelium has changes consistent with regeneration with nuclear enlargement (arrow), nucleoli, and a round nuclear outline as opposed to the flattened nuclei we saw in the normal mucus producing cells. These findings indicate activation of the mechanisms producing acute inflammation but do not allow us to differentiate between varied aetiologies such ASLC produced by Campylobacter, other acute bacterial infection, first episode ED, trauma, toxins etc. This case was culture proven Campylobacter jejune.


(Image Contrib. by:UCHC)(Description by: Marin Nadel, M.D.)
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Acute Colitis
Etiology

•Acute colitis has a wide spectrum of causes. Among the more common are:

•Infection including viruses, bacteria, fungus and parasites

•Vascular, usually small vessel disease

•Idiopathic including first onset ulcerative colitis

Pathogenesis

•See individual diseases

Epidemiology

•The major cause of acute colitis is infectious, with the incidence and organism varying widely on a geographic and socioeconomic basis

•Ischemic colitis is a disease of the elderly and more affluent populations with an atherosclerotic prone diet

•See individual disease for a more complete discussion

Clinical

•See individual diseases

General Gross Description

•See individual diseases

General Micro Description

•See individual disease

Reference

• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 790-806


• Current literature from PubMed at National Library of Medicine

Synopsis by: Martin Nadel, M.D., UCHC
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