Low Grade Dysplasia and Regenerative Changes in IBD

Low Grade Dysplasia and Regenerative Changes in IBD •The crypt on the right show the features of low grade dysplasia with enlarged crowded hyperchromatic nuclei •The dysplasia is low grade because there is not significant loss of polarity •The crypt on the left shows regenerative changes with the nuclei being round, having small nucleoli, less increase in nuclear chromatin, and maintaining a basal orientation •The distinction between dysplasia and regeneration can be difficult as shown in this image, and a diagnosis of dysplasia should only be made when it is clearcut (Description By:Martin Nadel, M.D. ) (Image Contrib. by:Martin Nadel, M.D. UCHC )