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| Normal Ileum |
| Etiology • Not applicable. |
| Pathogenesis • Not applicable., |
| Epidemiology • Not applicable. |
| General Gross Description • Distal 60% of small bowel beyond ligament of Treitz • Thinner wall and smaller lumen than jejenum • Less prominent plicae, fattier mesentery • Mostly located in lower abdomen • Supplied by superior mesenteric artery |
| General Microscopic Description • Mucosa thrown up in plicae and arranged in villi to maximize absorptive area • Villi project above surface; crypts of Lieberkuhn extend between the villi to the muscularis mucosa • Villi lined by absorptive tall columnar cells and goblet cells • One intraepithelial T lymphocyte/5 glandular cells • Scattered endocrine cells • Crypts contain stem cells, endocrine cells, and Paneth cells with supranuclear, eosinophilic granules • Plasma cells, lymphocytes, mast cells, eosinophils, and histiocytes normal in lamina propria • Submucosa beneath the muscularis mucosa, contains Meissner's plexus of ganglion cells and nerves • Muscularis propria with inner circular and outer longitudinal layers separated by Auerbach's plexus • Outer surface covered by visceral peritoneum • Mucosal/submucosal lymphoid follicles termed Peyer's patches. |
| Clinical Correlation • Not applicable. |
| References • Histology for Pathologists. Sternberg SS ed. New York: Raven Press, 1992. pp. 547-56 |
| Normal Ileum |
| Synopsis by: Melinda Sanders M.D. (T65200M00100)[539] |
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