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| Small Intestinal Atresia |
| Etiology • Unknown. |
| Pathogenesis • Theories include: • Failure to recanalize solid lumen leading to single area of atresia or multiple sites • Ischemia due to mechanical obstruction such as intussusception • Meconium ileus leading to inflammation and obstruction, |
| Epidemiology • Duodenal atresia in 1:5000 live births; frequently associated with Down's syndrome or other anomalies • Jejuno-ileal atresia ranges from 1:1500 to 1:20,000; usually not associated with other anomalies |
| General Gross Description • Most duodenal atresia either exhibits a mucosal membrane or two lumens connected by a cord • Jejuno-ileal atresia may show these patterns or multiple isolated segments. |
| General Microscopic Description • Variety of histologic pictures; may be inflammation, meconium extravasation and fibrosis or may simply be an absence of lumen or entire bowel wall. |
| Clinical Correlation • Present relatively early in life with vomiting • Treated surgically |
| References • Dimmick JE, Kalousek DK. Developmental Pathology of the Embryo and Fetus. Philadelphia: Lipincott. 1992. pp. 519-524. • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. pp. 787. |
| Small Intestinal Atresia |
| Synopsis by: Melinda Sanders M.D. (T64000M20400)[533] |
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