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| Candidal Ulcer of Stomach |
| Etiology • Candida |
| Pathogenesis • Fungal invasion of epithelium and submucosa • Accompanied by acute and chronic inflammation., |
| Epidemiology • Immunocompromised or debilitated hosts • Diabetics • Associated with oral and esophageal candidiasis • Usually not diagnosed ante-mortem • Candida may colonize preexisting ulcers including those associated with malignancy |
| General Gross Description • Yellowish plaques • May cover part or all of preexisting ulcer base |
| General Microscopic Description • Characteristic pseudohyphae which do not branch. • Blastocysts also seen. • Stains such as periodic-acid-Schiff (PAS) and Gomori methenamine silver (GMS) will highlight fungal walls |
| Clinical Correlation • Infections usually not recognized clinically • Colonization of preexisting ulcers may be identified on biopsy or cytologic examination. |
| References • Diagnostic Surgical Pathology, 2d edition, Sternberg SS (ed). Philadelphia: Lippincott-Raven,1996, p. 1287. |
| Candidal Ulcer of Stomach |
| Synopsis by: Melinda Sanders M.D. (T63000D05570)[527] |
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