• The liver is in cross section.
• The arrows point to a lesion which is found at the periphery extending to the capsule.
• The normal parenchyma is replaced by gray tan tissue.
•Blockage of intra-hepatic blood vessels by tumor or
vasculitis can result in infarcts of the liver.
•Another important cause of hepatic infarcts is sickle cell disease.
•Blockage of arterial blood flow results in anoxic
cell injury and the development of an infarct.
•Blockage of the portal vein does not usually result in an infarct because the portal artery continues to provide the liver cells with oxygen
•Liver infarcts are rare because of the dual blood supply.
•May present as pain the upper right quadrant.
|General Gross Description|
•Blockage of the intrahepatic artery can result in
typical wedge shaped pale infarcts.
•Occlusion of the portal vein does not result in an
infarct because of the hepatic arterial blood supply.
•However, an area of mottled discoloration may be seen, referred to as an infarct of Zahn.
|General Micro Description|
•Infarcts due to occlusion of the hepatic artery are characterized by coagulative necrosis of the liver cells, followed by infiltration by inflammatory cells, resorption of tissue and the development of a scar.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 871