• A single focus of lymphoma in the liver.

• The white arrow points to a tan-gray nodule replacing the normal parenchyma of the liver by a deposit of lymphoma.

•Unknown

•Unknown

•Involvement of the liver in systemic lymphomas occurs in approximately 50% of all cases.

•Any form of lymphoma (Hodgkins or non-Hodgkins Disease) can involve the liver.

•Clinical sequelae of hepatic involvement by lymphoma can be none to extensive with the development of symptoms of liver cell function compromise, including jaundice, elevation of serum enzymes and coagulopathy.
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•Grossly, the liver shows some evidence of involvement depending upon the extent of tumor.

•Occasionally, nodular deposits may be seen.

•Microscopically, the lymphoma looks like that seen in lymph nodes.

•The earliest involvement in the liver involves the portal triads in the form of nodular aggregates of lymphoid cells.

•Such involvement, if extensive, can spill into the periportal area of the liver parenchyma.

• Current literature from PubMed at National Library of Medicine