Lymphoma
Lymphoma

• A single focus of lymphoma in the liver.

• The white arrow points to a tan-gray nodule replacing the normal parenchyma of the liver by a deposit of lymphoma.


(Image Contrib. by:UCHC)(Description by: T.V.Rajan, M.D.)
T56000M81406
Pathweb's Virtual Museum Home  eSynopsis of Pathology  eAtlas of Pathology
Lymphoma
Etiology

•Unknown


Pathogenesis

•Unknown


Epidemiology

•Involvement of the liver in systemic lymphomas occurs in approximately 50% of all cases.

•Any form of lymphoma (Hodgkins or non-Hodgkins Disease) can involve the liver.


Clinical

•Clinical sequelae of hepatic involvement by lymphoma can be none to extensive with the development of symptoms of liver cell function compromise, including jaundice, elevation of serum enzymes and coagulopathy.
Visit National Cancer Institute for Current Treatment


General Gross Description

•Grossly, the liver shows some evidence of involvement depending upon the extent of tumor.

•Occasionally, nodular deposits may be seen.


General Micro Description

•Microscopically, the lymphoma looks like that seen in lymph nodes.

•The earliest involvement in the liver involves the portal triads in the form of nodular aggregates of lymphoid cells.

•Such involvement, if extensive, can spill into the periportal area of the liver parenchyma.


Reference
No suitable textbook reference


• Current literature from PubMed at National Library of Medicine


Synopsis by: T.V.Rajan, M.D., Ph.D., UCHC
Pathweb's Virtual Museum Home  eSynopsis of Pathology  eAtlas of Pathology