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| Adenocarcinoma |
| Etiology • Unknown. |
| Pathogenesis • May follow the adenoma-carcinoma sequence as discussed in the description of colon adenocarcinoma • May complicate Crohn's disease or Peutz-Jegher's syndrome, |
| Epidemiology • May occur in Lynch syndrome, type II • Usually elderly patients • Approximately 50% in duodenum in periampullary region • An order of magnitude less frequent than colon carcinomas |
| General Gross Description • Duodenal lesions are often papillary consistent with origin in villous adenoma • More distal lesions may be obstructing or may be ulcerated |
| General Microscopic Description • Intestinal type carcinomas with neoplastic cells forming glands, some of which show cribriform configuration with central necrosis and inflammation • Elongated, hyperchromatic nuclei with nucleoli |
| Clinical Correlation • Duodenal lesions discovered with occlusion of biliary and/or pancreatic drainage • Distal lesions often discovered at an advanced stage as liquid contents can progress past tight obstruction |
| References • Rosai J: Ackerman's Surgical Pathology. 8th ed. St. Louis, Mosby-YearBook, 1996, pp. 686. |
| Adenocarcinoma |
| Synopsis by: Melinda Sanders M.D. (T64000M81403)[535] |
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