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| Bergers Glomerulonephritis |
| Etiology •Probably infectious, especially mucosal infections in respiratory or gastrointestinal tracts. |
| Pathogenesis •The disease is defined by the presence of IgA immune complexes in the glomerular tufts. Presumably mucosal derived IgA combines with antigens to form circulating immune complexes that deposit in the glomerular mesangium., |
| Epidemiology •This disease is probably the most common form of glomerulonephritis world wide. •The disease tends to be mild and relatively asymptomatic so many cases are undiagnosed. •Some cases seem to be related to mucosal infections such as respiratory infections and gastrointestinal disorders such as celiac disease and hepatic diseases. •Immunogenetics, DR4, ?HLA Bw35. |
| General Gross Description •The kidneys in Berger's glomerulonephritis show no gross abnormalities that reflect the pathologic process. |
| General Microscopic Description •Berger's disease is a mild form of IgA glomerulonephritis. •The glomeruli show modest increase in mesangial cellularity. •Direct immunofluorescence shows IgA and C3 granular fluorescence in a mesangial pattern. •Electron microscopy shows immune complex type dense deposits in the mesangium. |
| Clinical Correlation •Clinically the patients are well and most cases are investigated because of hematuria that has been detected incidentally, such as part of a routine physical examination. •On occasions, the patients relate discolored urine following respiratory infections. |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 956-957. •Rose B. Renal Pathophysiology the essentials. Baltimore: Williams and Wilkins. 1994. Ch. 9. |
| Bergers Glomerulonephritis |
| Synopsis by: Harold Yamase M.D. (T71200M00043)[218] |
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