| Prostatic Hyperplasia
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Etiology
•Unknown, but must involve endogenous hormonal changes that occurs with the aging process.
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Pathogenesis
•Still uncertain. Dihydrotestosterone required. Increased intraprostatic
estrogen or dihydrotestosterone,
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Epidemiology
•Extremely common disorder in men over the age of 50.
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General Gross Description
•The prostate gland is enlarged (normal adult prostate gland weighs approximately 20 grams).
•On cut surface, multiple nodules of varying sizes are noted in the parenchyma.
•The nodules may be solid or variably solid and cystic.
•The central periurethral portion of the prostate gland is more severely affected and may completely obstruct the urethral luminal patentcy.
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General Microscopic Description
•The nodules may vary in the composition of glandular epithelial hyperplasia and fibromuscular stromal hyperplasia.
•The glandular hyperplastic component not infrequently shows irregular sized glandular spaces lined by infoldings of benign epithelium showing the inner columnar layer and another flattened myoepithelial cell layer.
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Clinical Correlation
•Symptoms of prostatic hyperplasia are related to urethral obstruction of urine outflow and include frequency, nocturia, difficulty in starting and stopping urine flow; dribbling and dysuria.
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1025-1026.
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| Prostatic Hyperplasia
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| Synopsis by: Harold Yamase M.D. (T77100M72440)[485]
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