Cloaca
Cloaca

• The dilated sac-like structure in the center of the photograph is a persistent cloaca. There has been failure in early fetal life of the urorectal septum to divide the rectum from the urogenital sinus.

• The photograph is a posterior view. Entering the cloaca are the colon, the right ureter and the left ureter (not shown). The cloaca served as rectum and bladder. There was no left kidney (renal agenesis). The infant had no anus.

• The only outlet was a thin narrow urethra.


(Image Contrib. by:UCHC)(Description by: H. Yamase, M.D.)
T74000M20000
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Persistent Cloaca
Etiology

•Unknown.


Pathogenesis

•The abnormality results from failure of the urorectal septum to separate the primitive urogenital sinus from the hindgut.


Epidemiology

•Developmental disorder detected prenatally or at birth.


Clinical

•Associated anomalies may include imperforate anus, abscence of genital and urinary orifices, megacolon, megaureters, renal dysplasia, renal agenesis.


General Gross Description

•The diagnosis rests on the gross demonstration of a common structure serving as bladder and rectum.


General Micro Description

•Not applicable.


Reference

•Textbook of Fetal and Perinatal Pathology. Wigglesworth JS and Singer DB (eds) Cambridge: Blackwell, 1989, pp. 1163-4.

•Langman^s Medical Embryology, 6th edition. 1990. Sadler TW. Baltimore: Williams and Wilkins. pp. 75, 255, 268.


• Current literature from PubMed at National Library of Medicine


Synopsis by: Harold Yamase M.D., UCHC
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