• Shown in the photograph is a calyx of the upper pole
with transitional cell carcinoma (T). The tumor
appears as a markedly thickened mucosal lesion.
The tumor growth appears luminal rather than
• Adjacent areas of the mucosa appear irregularly thickened (arrows). These areas were also histologically transitional cell carcinoma.
|Transitional cell carcinoma|
•Similar to transitional cell carcinoma of the bladder.
•Patients with analgesic abuse nephropathy have increased risk for developing transtional cell carcinoma of the renal pelvis.
•Same as for transitional cell carcinoma of the bladder.
•Similar to transtional cell carcinoma of the bladder.
•Hematuria is a common presentation.
location in the renal pelvis, patients may present with the clinical picture
of urine outflow obstruction and hydronephrosis.
•Generally there is no
palpable mass on presentation.
|General Gross Description|
•The carcinoma predominantly involves the mucosal surfaces of the renal
pelvis and calyces and may secondarily invade the renal parenchyma.
tumor is papillary to nodular on viewing from the mucosal aspect.
•Tumors involving the uretero-pelvic junction may obstruct urine outflow and cause hydronephrosis.
|General Micro Description|
•The tumor histologically tends to show a papillary
•The papillae show a central fibrovascular core and are
lined by transitional epithelial cells.
•The neoplastic transitional epithelial cells show varying degrees of nuclear changes which is the basis for tumor grading.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 987-988.