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| Congenital Mesoblastic Neprhoma |
| Etiology •Unknown. |
| Pathogenesis •Unknown., |
| Epidemiology •Usually discovered in the first 3 months of life. •Believed to be congenital and may be discovered prior to birth by ultrasound studies. •Has been reported in children with the Beckwith-Wiedemann syndrome. •There is no sex predilection. |
| General Gross Description •This renal tumor is usually solitary and unilateral. •On cut surface the tumor is usually light tan, fleshy and has ill-defined peripheral borders, blending into the adjacent renal parenchyma. |
| General Microscopic Description •The tumor is microscopically monomorphic, composed of spindled shape cells. •The tumor cells resemble fibroblasts with scant interstitial collagen. •At the periphery, the tumor extends into the adjacent renal parenchyma with minimal compression and distortion. |
| Clinical Correlation •The tumor is believed to be congential and may be discovered prior to birth by ultrasound studies. •Most cases are discovered in the first few months of life because of presentation as an abdominal mass. •There may be maternal polyhydramnios. •Patients with hypercalcemia have been reported. |
| References •Murphy WM, Beckwith JB, and Farrow GM. Tumors of the Kidney, Bladder, and Related Urinary Structures, Washington: AFIP, 1994, pp. 55-67. |
| Congenital Mesoblastic Neprhoma |
| Synopsis by: Harold Yamase M.D. (T71000M88000)[235] |
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