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| Liposarcoma |
| Etiology •Unknown. |
| Pathogenesis •Unknown., |
| Epidemiology •Usually diagnosed in the fifth to seventh decade of life. •Uncommon in children. |
| General Gross Description •Tumors are usually large, especially those occuring in the retroperitoneum. •Tumors are usually well-circumscribed, encapsulated and lobulated. •The cut surface is variable depending on the histologic type. •Tumors may resemble adipose tissue, may have a gelatinous appearance or may be fleshy and solid with variable areas of necrosis and hemorrhage. |
| General Microscopic Description •Liposarcomas are divided into four histologic types: well-differentiated, myxoid, round cell, and pleomorphic. •Well-differentiated liposarcomas closely resemble adipose tissue with varying degrees of atypical features. •Myxoid liposarcomas show abundant extracellular mucinous ground substance and scattered adipose cells some containing multiple small lipid vacuoles (lipoblasts).There is usually a prominent capillary vascular network •Round cell liposarcomas are cellular neoplasms with varying degrees of lipoblastic differentiation. •Pleomorphic liposarcomas are cellular neoplasms composed of pleomorphic tumor cells. |
| Clinical Correlation •Liposarcomas present as mass lesions. •The two most common sites are the extremities especially the thigh and the retroperitoneum. •Recurrent lesions are not unusual. •High grade tumors correlate with metastatic potential, usually to lung via hematogenous route.. |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1262-1263. •Enzinger FM, Weiss SW. Soft Tissue Tumors. St. Louis: Mosby, 1985, pp. 431-466. |
| Liposarcoma |
| Synopsis by: Harold Yamase M.D. (T71000M88523)[465] |
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