|
|
| Hypospadias |
| Etiology |
•Developmental abnormality. •There is some evidence for genetic influences; sibling of a child with hypospadias has an increased (14%) chance of having hypospadias. |
| Pathogenesis |
•Developmental malformation of the urethral groove and formation of the urethral canal. |
| Epidemiology |
•Hypospadias is one of the more common congenital malformations, occuring in the United States at a frequency of 28.23 per 10,000 total births. |
| Clinical |
•Usually does not need surgical correction. |
| General Gross Description |
•Hypospadias is the abnormal location of the urethral meatus ventral to
the normal glanular tip. •The urethral meatus may open on the ventral surface of the penis, at the base of the penis or the perineum. |
| General Micro Description |
•No specific microscopic features. Hypospadias is a gross anatomic abnormality. |
| Reference |
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 440 and 1007. •Neonatology, 4th edition, Avery et al. (eds), New York: Lippincott, 1994. pp. 905-906.
|
