• Spindle cells with elongated, regular nuclei.

• No mitoses.

• No prominent nucleoli.

•unknown

•unknown

•clonal, estrogen sensitive

•extremely common neoplasm affecting 25% of reproductive age women

•vast majority are asymptomatic

•Cellular leiomyoma are quite unusual

•most patients are completely asymptomatic

•symptoms, if present, include heavy, painful menses, pelvic fullness, infertility, spontaneous miscarriage, urinary symptoms due to pressure on bladder

•estrogen sensitive with occasional rapid growth during pregnancy; atrophy after menopause

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•solitary or multiple well circumscribed neoplasms

•may be submucosal, intramural or subserosal with pedunculation

•whorled, bulging, rubbery, white cut surface

•variety of degenerative changes including hemorrhagic, cystic, mucinous, fatty, myxoid, fibrotic may be found

•composed of spindle cells with blunt ended elongate bland
nuclei and thin elongated cytoplasm

•cells arranged in interlacing bundles

•Lesion may be intensely cellular with scant cytoplasm

•Little atypia or mitoses in cellular leiomyoma

• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1059-60

• Current literature from PubMed at National Library of Medicine