C.I.N. 3 (Carcinoma in situ) of Cervix
C.I.N. 3 (Carcinoma in situ) of Cervix

View of the cervix at the squamo-columnar junction (red arrow).
Both surface epithelium and the endocervical clefts (blue arrows) are replaced by abnormal squamous epithelium which lacks maturation.
The involvement of endocervical clefts does NOT imply invasion since they are in continuity with the surface.
Black tint on surface (black arrows) is due to india ink applied in the pathology department.
(Description By:Melinda Sanders,M.D. )
(Image Contrib. by:Melinda Sanders,M.D. UCHC )