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| Herpes Virus Infection |
| Etiology • Usually Herpes simplex virus type II • Sexually transmitted |
| Pathogenesis • DNA virus which infects squamous epithelium • Viral replication results in cytopathic changes in the cell and cell death, |
| Epidemiology • Risks include many sexual partners • Also partner with many partners |
| General Gross Description • Painful red lesions that blister and then ulcerate |
| General Microscopic Description • Characteristic nuclear enlargement and frequent multinucleation • Nuclei within the multinucleated cells mold to each other • Huge intranuclear pink purple inclusions (Cowdry type A) • Inflamed submucosa with ulceration of the epithelium |
| Clinical Correlation • First lesions appear 3-7 days after exposure • Recrudescence may occur intermittently |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 340-1, 1038. |
| Herpes Virus Infection |
| Synopsis by: Melinda Sanders M.D. (T83000E38500)[277] |
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