• Two multinucleated cells are shown.
• Nuclei compress each other with molding.
• Nuclear chromatin is not visible, nor are nucleoli.
• Cytoplasm is scant and basophilic.
|Herpes Virus Infection|
• Usually Herpes simplex virus type II
• Sexually transmitted
• DNA virus which infects squamous epithelium
• Viral replication results in cytopathic changes in the cell and cell death
• Risks include many sexual partners
• Also partner with many partners
• First lesions appear 3-7 days after exposure
• Recrudescence may occur intermittently
|General Gross Description|
• Painful red lesions that blister and then ulcerate
|General Micro Description|
• Characteristic nuclear enlargement and frequent multinucleation
• Nuclei within the multinucleated cells mold to each other
• Huge intranuclear pink purple inclusions (Cowdry type A)
• Inflamed submucosa with ulceration of the epithelium
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 340-1, 1038.