| • Two multinucleated cells are shown.
• Nuclei compress each other with molding.
• Nuclear chromatin is not visible, nor are nucleoli.
• Cytoplasm is scant and basophilic. |
| • Two multinucleated cells are shown.
• Nuclei compress each other with molding.
• Nuclear chromatin is not visible, nor are nucleoli.
• Cytoplasm is scant and basophilic. |
| Herpes Virus Infection |
| Etiology |
• Usually Herpes simplex virus type II
• Sexually transmitted |
| Pathogenesis |
• DNA virus which infects squamous epithelium • Viral replication results in cytopathic changes in the cell and cell death |
| Epidemiology |
• Risks include many sexual partners • Also partner with many partners |
| Clinical |
• First lesions appear 3-7 days after exposure • Recrudescence may occur intermittently |
| General Gross Description |
• Painful red lesions that blister and then ulcerate |
| General Micro Description |
• Characteristic nuclear enlargement and frequent multinucleation • Nuclei within the multinucleated cells mold to each other • Huge intranuclear pink purple inclusions (Cowdry type A) • Inflamed submucosa with ulceration of the epithelium |
| Reference |
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 340-1, 1038.
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