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| Leiomyoma |
| Etiology •unknown |
| Pathogenesis •unknown •clonal, estrogen sensitive, |
| Epidemiology •extremely common neoplasm affecting 25% of reproductive age women •vast majority are asymptomatic |
| General Gross Description •solitary or multiple well circumscribed neoplasms •may be submucosal, intramural or subserosal with pedunculation •whorled, bulging, rubbery, white cut surface •variety of degenerative changes including hemorrhagic, cystic, mucinous, fatty, myxoid, or fibrotic may be found |
| General Microscopic Description •composed of spindle cells with blunt ended elongate bland nuclei and thin elongated cytoplasm •cells arranged in interlacing bundles •may see cytological atypia which is acceptable in the absence of mitoses •may see necrosis or hemorrhage |
| Clinical Correlation •most patients are completely asymptomatic •symptoms, if present, include heavy, painful menses, pelvic fullness, infertility, spontaneous miscarriage and urinary symptoms due to pressure on bladder •estrogen sensitive with occasional rapid growth during pregnancy; atrophy after menopause |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1059-60 |
| Leiomyoma |
| Synopsis by: Melinda Sanders M.D. (T85000M88900)[24] |
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