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| Maligant Mixed Mullerian Tumor |
| Etiology •unknown •unassociated with unopposed estrogen |
| Pathogenesis •unknown, |
| Epidemiology •post-menopausal women •1-2% of uterine corpus malignancies |
| General Gross Description •fungating intraluminal neoplasms with poorly circumscribed borders which are often very bulky •hemorrhagic and necrotic •may protrude through the cervical os |
| General Microscopic Description •composed of malignant epithelial and stromal components •adenocarcinoma and/or squamous carcinoma •stromal sarcoma or leiomyosarcoma (homologous) or •osteosarcoma, chrondrosarcoma or fibrosarcoma (heterologous) |
| Clinical Correlation •symptoms of post-menopausal bleeding •spreads contiguously and usually to regional lymph nodes (like carcinoma) as well as hematogenously to lungs (like sarcoma) •treated with surgery +/- radiation therapy •prognosis related to extent of disease •overall 5 yr survival of 25-30% |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1062 |
| Maligant Mixed Mullerian Tumor |
| Synopsis by: Melinda Sanders M.D. (T84000M89513)[22] |
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