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Trophoblast Inclusions (40X)
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Trophoblast Inclusions (40X)

The arrow points to one of two trophoblast inclusions.
The trophoblast is identical to that seen on the surface of the villus.
The stroma is loose with wavy nuclei.
The villi are typical of the first trimester.
(Description By:Melinda Sanders,M.D. )
(Image Contrib. by:Melinda Sanders,M.D. UCHC )
Trophoblast Inclusions
Etiology

Unknown.
Pathogenesis

Due to cross sections of deeply infolded villous contours,
Epidemiology

Increased in triploid gestations, particularly partial moles.
May also be increased in aneuploid gestations with other chromsome counts
General Gross Description

Microscopic finding
General Microscopic Description

Intravillus finding composed of syncytio- and/or cytotrophoblast
Maternal blood may be contained within the inclusion
Clinical Correlation

Outcome dependent on underlying pathology
References

Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 670-671.
Trophoblast Inclusions
Synopsis by: Melinda Sanders M.D. (T88100M20000)[425]
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