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Brenner Tumor of Ovary (40X)
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Brenner Tumor of Ovary (40X)

The arrows point to the epithelial cell component of a Brenner tumor.
The cells have little orientation with reference to the "lumen" or cystic space in the upper right hand corner.
The nuclei are relatively uniform, lacking pleomorphism, hyperchromasia or macronucleoli.
There is a moderate amount of eosinophilic cytoplasm.
The stroma is cellular and composed of spindly cells.
Mitoses are not identified.
(Description By:Melinda Sanders, M.D. )
(Image Contrib. by:Melinda Sanders, M.D. UCHC )
Brenner Tumor
Etiology

unknown
Pathogenesis

unknown,
Epidemiology

peri- or postmenopausal women
only 10% bilateral
General Gross Description

solid or cystic
yellow-tan, firm
frequently microscopic
General Microscopic Description

nests or cysts of cells resembling urothelium
generally bland, monotonous, benign nuclei
Clinical Correlation

virtually always benign; malignant counterpart which is rare resembles transitional cell carcinoma of bladder
usually asymptomatic until achieve large size
may accompany mucinous neoplasm
cured with simple resection
References

Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1070
Brenner Tumor
Synopsis by: Melinda Sanders M.D. (T87000M90000)[44]
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