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Malignant Mixed Mesodermal Tumor of Ovary (Close up cut surface)
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Malignant Mixed Mesodermal Tumor of Ovary (Close up cut surface)

Cut surface of an ovary totally replaced by neoplasm.
Regions of tan firm tissue alternating with hemorrhage and necrosis.
Small cystic foci (probably due to necrosis).
(Description By:Melinda Sanders, M.D. )
(Image Contrib. by: UCHC )
Malignant Mixed Mesodermal Tumor
Etiology

Unknown
Pathogenesis

unknown
some cases associated with endometriosis,
Epidemiology

Post-menopausal women
Low parity
Rare neoplasm
General Gross Description

Large variegated lesions with areas of necrosis and hemorrhage
May have adhesions
General Microscopic Description

epithelial component most often serous or endometrioid with focal squamous differentiation
stroma may be spindle cell or show cartilage, skeletal muscle, smooth muscle or other soft tissue differentiation
Clinical Correlation

2-3% of ovarian neoplasms
Post-menopausal women
Usually has spread in the peritoneal cavity at surgery
Debulking and chemotherapy utilized
References

Le T,Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20-year experience.Gynecol Oncol 65(2), 237-240(1997)
Dictor M, Malignant mixed mesodermal tumor of the ovary: a reportof 22 cases. Obstet Gynecol 65(5), 720-724 (1985)
Malignant Mixed Mesodermal Tumor
Synopsis by: Melinda Sanders M.D. (T87000M89513)[255]
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