| Normal Villi
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Etiology
• Not applicable
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Pathogenesis
• Not applicable,
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Epidemiology
• Not applicable
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General Gross Description
• Spongy red tissue comprising the bulk of the placenta bounded by fetal surface (chorionic plate) and maternal surface (basal plate)
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General Microscopic Description
• Early in gestation villi are covered by a complete layer of syncytiotrophoblast overlying a complete layer of cytotrophoblast.
• Trophoblast is keratin positive but serves as endothelium for intervillous space.
• At term there is a single trophoblast layer with scattered knotted synctial trophoblast nuclei
• Trophoblast rests on basement membrane
• Interior of villus contains connective tissue, Hofbauer cells (macrophages) and fetal vasculature which proliferates and ramifies throughout gestation
• By term, the terminal villi contain vasculosyncytial membranes in which the basement membrane of the fetal capillary apposes the basement membrane of the trophoblast
• During gestation the terminal villi diminish in cross sectional area and have progressively larger cut surface composed of vascular profiles
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Clinical Correlation
• Not applicable
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References
• Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 116-142.
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| Normal Villi
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| Synopsis by: Melinda Sanders M.D. (T88220M00100)[432]
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