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| Atypical Proliferating Epithelial Neoplasm (Borderline Tumors) |
| Etiology •unknown |
| Pathogenesis • Unknown. • May derive from surface epithelium of ovary or from endometriotic implants , |
| Epidemiology • Increases with increasing age • Upward trend in incidence • 15% of all ovarian epithelial neoplasia |
| General Gross Description • The serous and mucinous neoplasms are both cystic and often multicystic. • Papillations may be identified grosly. • Endometrioid and clear cell types are exceedingly rare. |
| General Microscopic Description • Neoplastic cells do not invade the ovarian stroma in these neoplasms. • Mucinous and serous tumors show epithelial stratification, mitotic activity and nuclear atypism also occur. • Serous neoplasms also show the formation of epithelial papillae. |
| Clinical Correlation • Patients present with pelvic mass, abdominal enlargement, or abdominal pain. • Peritoneal implants (non-invasive) may occur and generate ascites. • Managed by surgery to debulk the neoplasm. • 5 year survival 93% |
| References • Harlow BL,Epidemiology of borderline ovarian tumors. J Natl Cancer Inst 78(1), 71-74 (1987) • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1067. |
| Atypical Proliferating Epithelial Neoplasm (Borderline Tumors) |
| Synopsis by: Melinda Sanders M.D. (T87000M84701)[256] |
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