Adenocarcinoma in Situ
Adenocarcinoma in Situ

•  To the left of the arrow are normal endocervical cells.

•  The nuclei are round to oval and basal with mucin in the cytoplasm.

•  To the right of the arrow the nuclei show loss of basal position.

•  The nuclei also show clumping and clearing of chromatin.

•  The N:C is massively increased.


(Image Contrib. by:UCHC)(Description by: Melinda Sanders, M.D.)
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Adenocarcinoma in situ of Cervix
Etiology

• Associated with human papilloma virus infection, especially type 18.


Pathogenesis

• Viral integration into host cell genome in fully malignant cells.


Epidemiology

• Multiple sexual partners.

• Partner with multiple partners.

• Same as sexually transmitted disease.


Clinical

• May be detected on routine pap smear but difficult to assess

• May be found in conjunction with invasive disease or squamous intraepithelial lesion

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General Gross Description

• Not grossly recognizable.


General Micro Description

• Columnar cells with enlarged, hyperchromatic nuclei

• Atypical nuclear chromatin

• Piling up of cells in epithelium with loss of polarity to surface

• Prominent nucleoli


Reference

• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052.


• Current literature from PubMed at National Library of Medicine


Synopsis by: Melinda Sanders M.D., UCHC
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