| • The arrows point to an intact basement membrane surrounding an endocervical cleft that is lined by glandular cells with malignant features.
• At this power the multiple cell layers lining the cleft are evident throwing the epithelium into papillae. |
| Adenocarcinoma in situ of Cervix |
| Etiology |
• Associated with human papilloma virus infection, especially type 18. |
| Pathogenesis |
• Viral integration into host cell genome in fully malignant cells. |
| Epidemiology |
• Multiple sexual partners. • Partner with multiple partners. • Same as sexually transmitted disease. |
| Clinical |
• May be detected on routine pap smear but difficult to assess • May be found in conjunction with invasive disease or squamous intraepithelial lesion |
| General Gross Description |
• Not grossly recognizable. |
| General Micro Description |
• Columnar cells with enlarged, hyperchromatic nuclei • Atypical nuclear chromatin • Piling up of cells in epithelium with loss of polarity to surface • Prominent nucleoli |
| Reference |
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052.
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