• The arrows point to an intact basement membrane surrounding an endocervical cleft that is lined by glandular cells with malignant features.
• At this power the multiple cell layers lining the cleft are evident throwing the epithelium into papillae.
|Adenocarcinoma in situ of Cervix|
• Associated with human papilloma virus infection, especially type 18.
• Viral integration into host cell genome in fully malignant cells.
• Multiple sexual partners.
• Partner with multiple partners.
• Same as sexually transmitted disease.
• May be detected on routine pap smear but difficult to assess
• May be found in conjunction with invasive disease or squamous intraepithelial lesion
|General Gross Description|
• Not grossly recognizable.
|General Micro Description|
• Columnar cells with enlarged, hyperchromatic nuclei
• Atypical nuclear chromatin
• Piling up of cells in epithelium with loss of polarity to surface
• Prominent nucleoli
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052.