• The glands are lined by cells with large hyperchromatic nuclei and scant cytoplasm.
• The large gland lumen at the top of the image shows necrotic debris.
• The stroma contains lymphocytes and plasma cells.
• Multiple layers of neoplastic cells can be seen lining the glands.
|Adenocarcinoma of Cervix|
• Associated with human papilloma virus infection, especially type 18.
• Account for up to 10% of carcinomas of the cervix
•integration into host genome of HPV with inactivation of p53
•area of active research
•sexually transmitted disease
•increased in cigarette smokers
•age peak at 40-45 but dropping
•women who have never had a pap smear or have not had one
in 5 years
• often detected later than squamous carcinoma because location makes pap smear screening more difficult
• comparable outcome to squamous carcinoma stage for stage
•For more information about prognosis and treatment, consult the NCI web site.
|General Gross Description|
•may be fungating, may be ulcerated but often deeply
•cut surfaces gray white, hard, poorly circumscribed
•necrosis and hemorrhage common
|General Micro Description|
• composed of glands with cells containing mucin vacuoles
• nuclei are round to oval, hyperchromatic, and have prominent nucleoli
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1053.