• The cells lining this complex gland are pseudostratified.
• The nuclei are elongated and hyperchromatic.
• Nucleoli are not prominent.
• The cells retain in general their orientation to the lumen.
with unopposed estrogen use
•may be exogenous (non-cycled estrogens) but generally
•endogenous due to peripheral aromatization of adrenal
androgens by adipose in obese women
•also associated with granulosa cell tumors and other estrogen producing ovarian tumors as well as polycystic ovary
•estrogen drives continued proliferation of the
•in the absence of progesterone maturation of the endometrium
and spiral arteries never occurs, nor does regular menses
•may also have diabetes and hypertension (classic triad)
|General Gross Description|
thick, tan endometrium measuring up 1.0 cms
|General Micro Description|
•glands exhibit crowding
and often show budding
•pseudostratified nuclei with mitotic activity
•cells retain orientation to the lumen
•cell nuclei have small nucleoli and normal chromatin
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1057-8