• The gland is round with a slit like lumen.
• The cells lining the gland show roudn to oval nuclei.
• The nuclei exhibit chromatin clearing (vesiculation).
• The nucleoli are prominent.
with unopposed estrogen use
•may be exogenous (non-cycled estrogens) but generally
•endogenous due to peripheral aromatization of adrenal
androgens by adipose in obese women
•also associated with granulosa cell tumors and other estro-
gen producing ovarian tumors as well as polycystic ovary
•estrogen drives continued proliferation of the
•in the absence of progesterone maturation of the endometrium
and spiral arteries never occurs, nor does regular menses
•may also have diabetes and hypertension (classic triad)
•asymptomatic or post-menopausal
|General Gross Description|
thick, tan endometrium measuring up 1.0 cms
|General Micro Description|
•glands exhibit crowding
and often show budding or dilatation
•stratified nuclei with mitotic activity
•cells lose orientation to the lumen
•nucleoli become prominent, nuclei become hyperchromatic or
show nuclear clearing or vesiculation
•no necrosis or stromal desmoplasia
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1057-8