| Amnion Band
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Etiology
• Rupture of the amnionic sac with free "bands" of amnion.
• Bands can wrap around fetal extremities and/or umbilical cord to cause amputation or demise
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Pathogenesis
• Unknown what causes rupture
• Bands entangle and mechanically constrict and amputate limbs,
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Epidemiology
• Spontaneous, usually not accompanying abnormal pregnancy
• 1/10,000 live births with signficant (30%) mortality rate
• Sporadic, non-recurrent
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General Gross Description
• Bands are delicate, fibrous and may be difficult to find
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General Microscopic Description
• Amnionic epithelium and mesoderm
• No inflammation and little degeneration
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Clinical Correlation
• Outcome dependent on what the band is wrapped around
• Unclear whether infants that fuse to the chorion often with massive limb or body wall defects are part of same syndrome.
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References
• Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 299-305
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| Amnion Band
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| Synopsis by: Melinda Sanders M.D. (T88100M29470)[419]
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