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| Malignant Melanoma of Vulva |
| Etiology • Unknown in this non-sun exposed area. |
| Pathogenesis • Unknown, |
| Epidemiology • Less than 5% vulvar cancers • Less than 2% melanomas • Post-menopausal women |
| General Gross Description • May be reddish plaque or pigmented plaque or nodule |
| General Microscopic Description • Composed of cells which infiltrate the mucosa, may nest at the mucosa-submucosal junction, and infiltrate underlying submucosa. • Large nuclei, very large nucleoli • May be epithelioid or spindle • May have numerous mitotic figures • Are not cohesive |
| Clinical Correlation • Prognosis dependent on the depth of invasion • Widely disseminates and is non responsive to most modalities of therapy • Localized lesions treated surgically. |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1043. |
| Malignant Melanoma of Vulva |
| Synopsis by: Melinda Sanders M.D. (T80100M87203)[268] |
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