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| Endometrial Stromal Sarcoma |
| Etiology •unknown |
| Pathogenesis •unknown, |
| Epidemiology •accounts for approximately 1-2% of endometrial malignancies •post-menopausal patients •not associated with estrogen excess |
| General Gross Description •intraluminal, friable, hemorrhagic gray white mass •may be fleshy |
| General Microscopic Description •proliferation of stromal cells without glands •poorly circumscribed with infiltrative borders •nuclei are hyperchromatic and pleomorphic with scant cytoplasm •mitoses are abundant in the high grade neoplasms |
| Clinical Correlation •patients present with post-menopausal vaginal bleeding •neoplasm invades locally but does not spread to regional lymph nodes •metasasizes via the blood stream to lungs •treatment by surgery |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1063 |
| Endometrial Stromal Sarcoma |
| Synopsis by: Melinda Sanders M.D. (T84000M89303)[21] |
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