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| Hodgkin's Disease, Lymphocyte Predominant Type |
| Etiology • Unknown |
| Pathogenesis • Very small population of neoplastic cells of L(ymphocyte) and H(istiocytic) subtype • Marked inflammatory reaction driven by cytokines secreted by neoplastic cells including IL 5 (attracting eosinophils), IL4, tumor necrosis factor alpha, GM-CSF, |
| Epidemiology • 0.7% of all new cancers in the U.S. overall for Hodgkin's Disease • Predominantly male and under 35 • Usually cervical lymph nodes • Relatively rare subtype |
| General Gross Description • Large fleshy tan node which may show ill defined nodularity |
| General Microscopic Description • Usually composed of small lymphoctyes, although histiocytes may be seen and may predominate (correct term is lymphocytic and/or histiocytic subtype • Difficult to find diagnostic binucleate Reed-Sternberg cells with eosinophilic macronucleoli ("owl eye" nuclei) • Polypoid mononuclear Reed-Sternberg variant with complex nuclear outline, chromatin clearing, and inconspicous nucleoli • Aberrant mitoses (ring shaped) • Mummified cells • Malignant cells demonstrate B cell markers including CD45+, CD30-, CD15- |
| Clinical Correlation • Tend to be confined to cervical lymph node(s) but may spread continguously • Carries an excellent prognosis |
| References • Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, 2nd edition, Philadelphia, W.B. Saunders, 1995, pp.141-151. |
| Hodgkin's Disease, Lymphocyte Predominant Type |
| Synopsis by: Melinda Sanders M.D. (T08000M96513)[320] |
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