| Hodgkin's Disease, Lymphocyte Depleted
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Etiology
• Unknown
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Pathogenesis
• Unlike other forms of Hodgkin's disease relatively large population of neoplastic cells
• Marked inflammatory reaction driven by cytokines secreted by neoplastic cells including IL 5 (attracting eosinophils), IL4, tumor necrosis factor alpha, GM-CSF,
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Epidemiology
• 0.7% of all new cancers in the U.S. are Hodgkin's Disease overall
• Present in older population
• Relatively rare
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General Gross Description
• Small, firm lymph nodes
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General Microscopic Description
• Large numbers of diagnostic Reed Sternberg cells and mononuclear variants which are CD15+, CD30+, CD45-, CD20-
• Background shows scant lymphocytes and may show abundant reticulin deposition or fibrosis
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Clinical Correlation
• Usually involves multiple lymph node groups
• Least likely to respond well to treatment
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References
• Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, 2nd edition. Philadelphia, W.B. Saunders, 1995, pp.172-178.
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| Hodgkin's Disease, Lymphocyte Depleted
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| Synopsis by: Melinda Sanders M.D. (T08000M96533)[322]
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