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Metastatic Adenocarcinoma
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Metastatic Adenocarcinoma

Cross section of a spleen showing a single focus of a metastatic adenocarcinoma:
Notice the replacement of the normal, darkly dark-red, splenic parenchyma by a deposit of a uniformly tan-gray nodule of tissue.
Splenic metastases, from malignancies elsewhere, are not common.
This phenomenon has been attributed to the elevated expression of fas ligand by splenic parenchyma.
(Description By:T. V. Rajan, M.D. )
(Image Contrib. by:Saint Francis Hospital Saint Francis Hospital )
Metastatic Adenocarcinoma
Etiology

Spread from primary source.
Pathogenesis

Tumor emboli are entrapped in the splenic circulation.,
Epidemiology

Rare and usually found at autopsy.
Occasionally presents as splenomegaly.
General Gross Description

Tan to gray white (depending on primary site)
General Microscopic Description

Dependent on histology of primary tumor.
Clinical Correlation

Usuallly not of clinical significance.
References

Sternberg SS (ed): Diagnostic Surgical Pathology, second edition. Philadelphia, Lippincott-Raven, 1996, pp. 753-4
Metastatic Adenocarcinoma
Synopsis by: Melinda Sanders M.D. (T07000M81406)[447]
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