Angiofibroma
Angiofibroma

•  This angiofibroma has been bivalved and the external view of both sides is demonstrated.

•  The neoplasm has a smooth surface which is yellow tan.

•  The areas of black discoloration represent hemorrhage.

•  They are likely to be the sources of epistaxis (nosebleed) that was a presenting symptom.


(Image Contrib. by:UCHC)(Description by: Melinda Sanders, M.D.)
T21000M91600
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Angiofibroma
Etiology

• Unknown

• Increases in size under the influence of testosterone


Pathogenesis

• Unknown


Epidemiology

• Predilection for teenage boys (peak incidence at age 15)

• Rarely ever seen in girls, if at all


Clinical

• Present with nasal obstruction and bleeding, as arise from lateral nasopharynx

• May bleed profusely with surgery, which is treatment of choice

• May need chemotherapy if surgery cannot remove intracranial extension

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General Gross Description

• Firm, fibrous masses

• Well circumscribed


General Micro Description

• Numerous vascular spaces embedded in stroma which is collagenized

• Spaces generally lined by single layer of endothelium


Reference

• Sternberg SS ed. Diagnostic Surgical Pathology, 2d edition, Lippincott-Raven; Philadelphia. 1996, pp. 874-5.


• Current literature from PubMed at National Library of Medicine


Synopsis by: Melinda Sanders M.D., UCHC
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