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| Bronchioloalveolar Carcinoma |
| Etiology • Unknown • Resembles an infectious disease in sheep--Jagziekte |
| Pathogenesis • Probably derives from terminal bronchiole alveolar complex, |
| Epidemiology • Affects patients from their 20's and older • Equal incidence in men and women • 1-9% of lung cancers |
| General Gross Description • Peripheral single nodule (coin lesion) or multiple nodules • May fuse into a diffuse involvement of lung • If mucinous, may be gelatinous appearing grossly |
| General Microscopic Description • Classically lines preexisting alveolar septae • Tall columnar cells containing mucin (Clara cell like) or • Columnar cells with extensive atypia and scattered mucin vacuoles |
| Clinical Correlation • Late symptoms if not discovered incidentally • Occasional patients may have extensive mucinous secretions in diffuse disease • Isolated lesions may be cured by surgery • Metastatic disease appears late |
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 725-6 |
| Bronchioloalveolar Carcinoma |
| Synopsis by: Melinda Sanders M.D. (T28000M82503)[233] |
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